Itchy E3 ubiquitin protein ligase (ITCH) is a gene that encodes a protein that belongs to the Nedd4 family of HECT domain E3 ubiquitin ligases. The protein functions in the transfer of ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates. This ubiquitin transfer tags the substrate protein for degradation. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as biliary tract cancer, intestinal cancer, and stomach cancer.

Related Pathways

Modified: December 4, 2015

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