Insulin receptor substrate 2 (IRS2) is a gene that encodes a protein of the same name that functions in regulating the effects of insulin-like growth factor 1 and insulin by mediating signaling between receptor tyrosine kinases and other associated proteins. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame insertions are observed in cancers such as esophageal cancer, intestinal cancer, and stomach cancer.

Related Pathways

Modified: December 4, 2015

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