Genes

IRF8

Interferon regulatory factor 8 (IRF8) is a gene that encodes a protein that functions as a regulatory transcription factor regulates the expression of genes stimulated by type I interferons (IFN-alpha and IFN-beta). Missense mutations, nonsense mutations, silent mutations, nonstop extensions, and frameshift deletions are observed in cancers such as skin cancer, stomach cancer, and upper aerodigestive tract cancer.

Modified: July 1, 2015

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