Interferon regulatory factor 8 (IRF8) is a gene that encodes a protein that functions as a regulatory transcription factor regulates the expression of genes stimulated by type I interferons (IFN-alpha and IFN-beta). Missense mutations, nonsense mutations, silent mutations, nonstop extensions, and frameshift deletions are observed in cancers such as skin cancer, stomach cancer, and upper aerodigestive tract cancer.

Modified: July 1, 2015

Disclaimer: The information presented at is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.