Interferon regulatory factor 4 (IRF4) is a gene that encodes a transcription factor protein that functions as a regulator of interferons and interferon-inducible genes. The protein is also a negative regulator of Toll-like-receptor (TLR) signaling. Fusions, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as hematopoietic and lymphoid cancers, intestinal cancer, and ovarian cancer.

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Modified: December 4, 2015

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