Interleukin 21 receptor (IL21R) is a gene that encodes a protein that functions as a cytokine receptor for interleukin 21. The protein also perpetuates the growth promoting signal of interleukin 21 that facilitates proliferation and differentiation of B-cells, T-cells, and natural killer (NK) cells. Fusions, missense mutations, and nonsense mutations are observed in cancers such as breast cancer, lung cancer, and ovarian cancer.

Modified: July 1, 2015

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