Interferon induced transmembrane protein 1 (IFITM1) is a gene that encodes an anti-viral protein that functions in the inhibition of viral entry into the cytoplasm of host cells. The protein is also important in the antiproliferative actions of interferon –gamma by inhibiting ERK activation or inhibiting cell cycle progression. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as breast cancer, cervical cancer, and intestinal cancer.

Modified: July 1, 2015

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