Genes

HIST1H4I

Histone cluster 1, H4i (HIST1H4I) is a gene that encodes a protein that belongs to the histone H4 family. The protein functions as a nuclear protein that participates in the formation of the nucleosome structure of chromosomal fibers in eukaryotes. The protein is important for transcription regulation, DNA repair, DNA replication, and chromosomal stability. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift insertions are observed in cancers such as breast cancer, endometrial cancer, and skin cancer.

Modified: July 1, 2015

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