Gephyrin (GPHN) is a gene that encodes
a protein that functions as a neuronal
assembly protein. The protein anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton.
The protein is also important for molybdenum
cofactor biosynthesis. Fusions, missense mutations,
and nonsense mutations are observed in cancers
such as intestinal cancer, liver cancer, and ovarian cancer.
July 1, 2015
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