Far upstream element (FUSE) binding protein 1 (FUBP1) is a gene that encodes a protein that functions as a single stranded DNA-binding protein. The protein binds to several DNA elements, including FUSE located on c-myc. The protein regulates c-myc in undifferentiated cells. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, and frameshift deletions and insertions are observed in cancers such as cancers of the central nervous system, intestinal cancer, and cancers of the upper aerodigestive tract.

Modified: July 1, 2015

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