Fibroblast growth factor receptor substrate 2 (FRS2) is a gene that encodes an adapter protein that links NGF and FGR receptors to downstream signaling pathways. The protein is also important for the activation of MAP kinases and PIK3R1. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Modified: July 1, 2015

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