Fms-related tyrosine kinase 3 (FLT3) is a gene that encodes for a tyrosine kinase that activates pathways in hematopoietic cells (Gene 2013) important in cellular proliferation. The FLT3 protein has an extracellular domain consisting of five immunoglobulin-like domains, a transmembrane domain, a juxtamembrane domain, and two tyrosine kinase domains (Leung, Man, and Kwong 2013).

FLT3 is frequently mutated in acute myeloid leukemia, myelodysplastic syndromes, other hematologic malignancies, and colorectal cancer (COSMIC​). Mutations in MDS are skewed towards the highest risk disease (refractory anemia with excess blasts).

Related Pathways

Contributors: Scott Wheeler, Ph.D. (through June 2014), Adam Seegmiller, M.D., Ph.D., Cindy L. Vnencak-Jones, Ph.D., Stephen A. Strickland, M.D., MSCI, Annette S. Kim, M.D., Ph.D.

Suggested Citation: Wheeler, S., Seegmiller, A., Vnencak-Jones, C.L., Strickland, S.A., Kim, A.S. 2016. FLT3. My Cancer Genome (Updated June 2016)

Modified: June 17, 2016

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