Fms-related tyrosine kinase 3 (FLT3) is a
gene that encodes for a tyrosine kinase that activates pathways in
hematopoietic cells (Gene
2013) important in cellular proliferation. The FLT3 protein has an extracellular
domain consisting of five immunoglobulin-like domains, a transmembrane domain, a
juxtamembrane domain, and two tyrosine kinase domains (Leung, Man, and
FLT3 is frequently mutated in acute myeloid leukemia, myelodysplastic syndromes, other
hematologic malignancies, and colorectal cancer (COSMIC).
Mutations in MDS are skewed towards the
highest risk disease (refractory anemia with excess blasts).
Wheeler, S., Seegmiller, A., Vnencak-Jones, C.L., Strickland, S.A., Kim, A.S. 2016.
My Cancer Genome
(Updated June 2016)
June 17, 2016
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