Genes

EPS15

Epidermal growth factor receptor pathway substrate 15 (EPS15) is a gene that encodes a protein that plays a role in the EGFR signaling pathway. The protein functions in receptor-mediated endocytosis of EGF and is found at clatherin-coated pits. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and urinary tract cancer.

Modified: July 1, 2015

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