The DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) gene encodes a protein involved in epigenetic gene regulation (Gene 2013; Li et al. 2007).

DNMT3A is most frequently mutated in hematologic malignancies such as acute myeloid leukemia and myelodysplastic syndromes, but it has also been observed in other cancers, including lung cancer (Kim et al. 2013).

Related Pathways

Contributors: Scott Wheeler, Ph.D. (through June 2014), Adam Seegmiller, M.D., Ph.D., Cindy L. Vnencak-Jones, Ph.D.

Suggested Citation: Wheeler, S., Seegmiller, A., Vnencak-Jones, C.L. 2015. DNMT3A. My Cancer Genome (Updated December 2015)

Modified: December 4, 2015

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