DDR2 (discoidin death receptor 2) is a
member of the DDR family of receptor
tyrosine kinases that are stimulated by
collagen rather than peptide growth
factors (Figure 1). Downstream signaling in cancer cells is poorly understood but may be via
SRC and STAT signaling pathways. Similar
to integrin receptors, DDR2 may play a
role in modulating cellular interactions with the extracellular matrix.
DDR2 mutations have been found at low
frequency in a number of cancers, including renal cell carcinoma, glioblastoma multiforme,
endometrial cancer, colorectal cancer (COSMIC).
The highest reported frequency is in squamous cell carcinoma of the lung (Hammerman
et al. 2011).
Figure 1. Schematic of DDR2 signaling pathway. Binding of collagen to DDR2 results in
activation of downstream signaling pathways.
The letter "K" within the schema denotes the tyrosine kinase
Paik, P.K. . 2015.
My Cancer Genome
(Updated December 2015)
December 7, 2015
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