DDR2 (discoidin death receptor 2) is a member of the DDR family of receptor tyrosine kinases that are stimulated by collagen rather than peptide growth factors (Figure 1). Downstream signaling in cancer cells is poorly understood but may be via SRC and STAT signaling pathways. Similar to integrin receptors, DDR2 may play a role in modulating cellular interactions with the extracellular matrix.

DDR2 mutations have been found at low frequency in a number of cancers, including renal cell carcinoma, glioblastoma multiforme, endometrial cancer, colorectal cancer (COSMIC). The highest reported frequency is in squamous cell carcinoma of the lung (Hammerman et al. 2011).


Figure 1.
Schematic of DDR2 signaling pathway. Binding of collagen to DDR2 results in activation of downstream signaling pathways. The letter "K" within the schema denotes the tyrosine kinase domain.

Related Pathways

Contributors: Paul K. . Paik, M.D.

Suggested Citation: Paik, P.K. . 2015. DDR2. My Cancer Genome (Updated December 2015)

Modified: December 7, 2015

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