Genes

CRLF2

Cytokine receptor-like factor 2 (CRLF2) encodes for a receptor protein that participates in activating STAT, possibly through JAK pathways. These pathways are important in immune system regulation. In cancer, CRLF2 rearrangements and one recurring mutation leading to CRLF2 overexpression have been identified in a subset of patients with high risk acute lymphoblastic leukemia who have an exceptionally dismal prognosis.

JAK and mTOR inhibitors have been explored in preclinical models as potential therapies targeting CRLF2-rearranged ALL (Maude et al. 2011; Tasian et al. 2012).

Related Pathways

Contributors: Valerie Brown, M.D., Ph.D., Scott C. Borinstein, M.D., Ph.D., Debra Friedman, M.D.

Suggested Citation: Brown, V., Borinstein, S.C., Friedman, D. 2015. CRLF2. My Cancer Genome https://www.padiracinnovation.org/content/gene/crlf2/ (Updated December 2015)

Modified: December 7, 2015

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