Genes

CREB3L1

cAMP responsive element binding protein 3-like 1 (CREB3L1) is a gene that encodes a protein that functions in the membrane of the endoplasmic reticulum. Under stress, the protein is cleaved and the releases cytoplasmic transcription factor domain enters the nucleus. Subsequently, the transcription factor domain activates the transcription of target genes. Fusions, missense mutations, nonsense mutations, silent mutations, nonstop extensions, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

Modified: July 1, 2015

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