Clathrin, heavy chain (Hc) (CLTC) is a gene that encodes a protein that functions as a component of the cytoplasmic face of intracellular organelles (coated vesicles and coated pits). The organelles are important for the intracellular trafficking of receptors and the endocytosis of macromolecules. Fusions, missense mutations, nonsense mutations, silent mutations are observed in cancers such as breast cancer, intestinal cancer, and ovarian cancer.

Modified: July 1, 2015

Disclaimer: The information presented at is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.