Checkpoint kinase 2 (CHEK2) is a gene that encodes a protein that functions as a regulator of the cell cycle as well as a tumor suppressor. The protein is activated in the presence of DNA damage in order to prevent entry into mitosis. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as cancers of the central nervous system, endometrial cancer, and intestinal cancer.

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Modified: December 4, 2015

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