Cyclin-dependent kinase inhibitor 1B (CDKN1B,
also known as p27) is a gene that encodes a protein that binds to and inhibits the
activation of cyclin E/CDK2 or cyclin D/CDK4 complexes in order to regulate cell cycle
progression at G1. Missense mutations, nonsense mutations, silent mutations, and frameshift
deletions and insertions are observed in cancers such as endometrial cancer, esophageal cancer,
and intestinal cancer.
December 4, 2015
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