CD274 molecule (CD274; also known as PDL1) is a gene that encodes a protein
that is known as programmed cell death 1 ligand 1 (PD-L1). The protein functions in the transmission of the costimulatory
signal that is needed for T-cell proliferation. Interaction with the protein inhibits T-cell activation and proliferation.
Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers
such as intestinal cancer, skin cancer, and stomach cancer.
January 19, 2017
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