Casitas B-lineage Lymphoma (CBL) proto-oncogene is a gene that encodes the CBL protein,
which is a RING finger E3 ubiquitin ligase. This ligase is an enzyme that functions in the
tagging of substrates for degradation by the proteasome. Fusions, nonsense and silent mutations are observed in cancers such as
acute myeloid leukemia, colorectal cancer, endometrial cancer, and skin cancer.
December 4, 2015
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