Core-binding factor, beta subunit (CBFB) is a gene
that codes for the beta subunit of the core binding factor protein. This protein
is thought to take part in normal hematopoiesis (Gene 2013a). CBFB is
involved in rearrangements observed in AML. Its role in cancer is also being investigated in
Myosin, heavy chain 11, smooth muscle (MYH11), is a gene
that encodes for a contractile protein in
2013b). MYH11 is involved in rearrangements observed in AML.
The CBFB-MYH11 fusion has been primarily observed in acute myeloid leukemia.
Seegmiller, A., Jagasia, M. 2013.
My Cancer Genome
(Updated June 2013)
June 4, 2013
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