Genes

CASP3

Caspase 3, apoptosis-related cysteine peptidase (CASP3) is a gene that encodes a protein that belongs to the cysteine-aspartic acid protease (caspase) family. The protein functions in the execution-phase of apoptosis induced by Fas. Caspase 3 cleaves and activates caspases 6, 7, and 9. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Related Pathways

Modified: December 4, 2015

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