Genes

BIRC3

Baculovial IAP repeat containing 3 (BIRC3) is a gene that encodes encodes the protein cellular inhibitor of apoptosis protein 2 (cIAP2), which inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2; cIAP2 is also a negative regulator of NF-κB signaling in B-cells through its ubiquitin-ligase activity, which targets the downstream protein kinase MAP3K14 for degradation by the proteasome (Bertrand et al. 2011; Buggins et al. 2010; Conze, Zhao, and Ashwell 2010; Foà et al. 2013; Li, Yang, and Ashwell 2002; Rossi et al. 2012; Zarnegar et al. 2008; Zhou et al. 2013).

BIRC3 is localized to chromosome 11q22, whose deletion is associated with high risk disease in patients with chronic lymphocytic leukemia. BIRC3 mutations are observed in <5% of patients with CLL (Baliakas et al. 2015; Chiaretti et al. 2014; Cortese et al. 2014; Rossi et al. 2012; Xia et al. 2015), ~11% of patients with Splenic marginal zone lymphoma (Rossi et al. 2011) and 6-10% of mantle cell lymphoma cases (Rahal et al. 2014).

Contributors: Nishitha Reddy, M.B.B.S., MSCI

Suggested Citation: Reddy, N. 2016. BIRC3. My Cancer Genome https://www.padiracinnovation.org/content/gene/birc3/ (Updated February 2016)

Modified: February 12, 2016

Disclaimer: The information presented at padiracinnovation.org is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.