Breakpoint cluster region (BCR) is a gene
that functions as a fusion partner with ABL1 to encode a fusion protein that is a result of the reciprocal translocation
between chromosomes 22 and 9. The
translocation produces the Philadelphia chromosome
– a hallmark feature of chronic myelogenous leukemia (CML). Fusions, rearrangements,
missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are
observed in cancers such as hematopoietic and lymphoid cancers, intestinal cancer, and skin
December 4, 2015
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