BCL6 corepressor (BCOR) is a gene that encodes a protein of the same name. BCOR is a member of the ankyrin repeat domain containing gene family. The corepressor expressed by BCOR binds to BCL6, a DNA-binding protein that acts as a transcription repressor for genes involved in regulation of B cells, a type of immune cell (Gene 2014a, 2014b; Genetics Home Reference 2014). In cancer, BCOR mutations have been observed in myelodysplastic syndromes, endometrial cancer, and other cancers.​

Contributors: Stephen A. Strickland, M.D., MSCI, Annette S. Kim, M.D., Ph.D.

Suggested Citation: Strickland, S.A., Kim, A.S. 2014. BCOR. My Cancer Genome (Updated September 2014)

Modified: September 23, 2014

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