Genes

BCL2L1

BCL2-like 1 (BCL2L1) is a gene that encodes a protein that is a member of the BCL-2 family. The protein functions in the regulation of outer mitochondrial membrane channel (VDAC) opening—a mechanism that regulates mitochondrial membrane potential and, ultimately, the induction of apoptosis. Fusions, rearrangements, Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, esophageal cancer, and lung cancer.

Modified: July 1, 2015

Disclaimer: The information presented at padiracinnovation.org is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.