BCL-2 antagonist/killer 1 (BAK1) is a gene that encodes a protein that is a member of the BCL2 protein family. The protein functions in the induction of apoptosis by aiding in the opening of the mitochondrial voltage-dependent anion channel to release cytochrome c. Missense mutations, nonsense mutations, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Related Pathways

Modified: December 4, 2015

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