Beta-2-microglobulin (B2M) is a gene that encodes a serum protein associated with the major histocompatibility complex (MHC) class I heavy chain on cell surfaces. Missense mutations, frameshift deletions, nonsense mutations, synonymous mutations, frameshift insertions, inframe deletions, and complex mutations are observed in cancers such as colon cancer, stomach cancer, and hematopoietic and lymphoid cancers.

Modified: January 7, 2016

Disclaimer: The information presented at is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.