Genes

ATR

ATR serine/threonine kinase (ATR) is a gene that encodes a protein that is a member of the PI3/PI4-kinase family. The protein functions in the phosphorylation of checkpoint kinase CHK1, RAD17, RAD9, and tumor suppressor protein BRCA1—proteins that are involved in the cell cycle and DNA damage signaling pathways. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

Related Pathways

Modified: December 4, 2015

Disclaimer: The information presented at padiracinnovation.org is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.