Additional sex combs like transcriptional regulator 1 (official symbol ASXL1) is a gene that codes for a chromatin-binding protein. Normal ASXL1 plays a role in embryonic development (Gene 2014). ASXL1 mutations are observed primarily in myelodysplastic syndromes, but they are also observed in colorectal and endometrial cancers (COSMIC).​

Related Pathways

Contributors: Stephen A. Strickland, M.D., MSCI, Annette S. Kim, M.D., Ph.D.

Suggested Citation: Strickland, S.A., Kim, A.S. 2015. ASXL1. My Cancer Genome (Updated December 2015)

Modified: December 4, 2015

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