APH1A gamma secretase subunit (APH1A) is a gene
that encodes a seven-transmembrane-domain protein
with an unknown function. The protein is a
member of the gamma secretase complex. The complex cleaves membrane proteins such as beta-amyloid precursor proteins and Notch receptors. Missense mutations,
silent mutations, and frameshift insertions
are observed in cancers such as bone cancer, lung cancer, and skin cancer.
July 1, 2015
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