APH1A gamma secretase subunit (APH1A) is a gene that encodes a seven-transmembrane-domain protein with an unknown function. The protein is a member of the gamma secretase complex. The complex cleaves membrane proteins such as beta-amyloid precursor proteins and Notch receptors. Missense mutations, silent mutations, and frameshift insertions are observed in cancers such as bone cancer, lung cancer, and skin cancer.

Modified: July 1, 2015

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