APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1) is a gene that encodes an apurinic/apyrimidinic (AP) endonuclease that participates in repair of AP sites, a type of DNA damage. Missense mutations, synonymous mutations, frameshift deletions, nonsense mutations, and frameshift insertions are observed in cancers such as colon cancer, ovarian cancer, and stomach cancer.

Modified: January 5, 2016

Disclaimer: The information presented at is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.