Apoptotic peptidase activating factor 1 (APAF1) is a gene that encodes a cytoplasmic protein that functions in the initiation of apoptosis. The protein also aids in the formation of an
apoptosome that binds and cleaves procaspase 9 into its activated form. Missense mutations, nonsense mutations, silent mutations,
and frameshift deletions and insertions are observed in cancers such as endometrial cancer,
intestinal cancer, and stomach cancer.
December 4, 2015
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