Apoptotic peptidase activating factor 1 (APAF1) is a gene that encodes a cytoplasmic protein that functions in the initiation of apoptosis. The protein also aids in the formation of an apoptosome that binds and cleaves procaspase 9 into its activated form. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

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Modified: December 4, 2015

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