AKT1 belongs to a family of serine-threonine protein
kinases which also includes AKT2 and AKT3.
AKT1 plays a key role in multiple cell processes, including growth, proliferation, survival,
and angiogenesis. AKT1 acts as a downstream mediator of phosphatidylinositol 3-kinase (PI3K; Figure
Figure 1. Schematic of the MAPK and PI3K
pathways. Growth factor binding to receptor
tyrosine kinase results in activation of
the MAPK signaling pathway
(RAS-RAF-MEK-ERK) and the PI3K pathway (PI3K-AKT-mTOR). The letter "K" within the schema
denotes the tyrosine kinase domain.
Lovly, C.M., Horn, L., Pao, W. 2015.
My Cancer Genome
(Updated December 2015)
December 7, 2015
Disclaimer: The information presented at padiracinnovation.org is compiled from sources
believed to be reliable. Extensive efforts have been made to make this information as accurate and as
up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed.
Despite our best efforts, this information may contain typographical errors and omissions. The contents
are to be used only as a guide, and health care providers should employ sound clinical judgment in
interpreting this information for individual patient care.