Ipilimumab in Extensive Stage Small Cell Lung Cancer

Drug class Target Agent Diseases Line of Therapy Status Source
CTLA-4 inhibitors, Immunotherapy, Monoclonal antibody CTLA-4 ipilimumab (Yervoy) small cell lung cancer metastatic Trials complete with results Reck et al. 2013; Antonia et al. 2015

The efficacy and safety of CTLA-4 inhibitors for the treatment of patients with small cell lung cancer (SCLC) is currently under investigation. Ipilimumab has shown potential in treating patients with extensive SCLC in a phase II trial (NCT00527735; Reck et al. 2013).

In a phase I/II study comparing treatment with nivolumab alone andversus nivolumab in combination with ipilimumab in patients with recurrent SCLC, the combination arm demonstrated higher response rates than the single agent arm (CA209-032; Antonia et al. 2015).

Reference Study Type / Phase Line of Treatment Treatment Agent # Patients in Study Response Rate PFS (months) OS (months)
Reck et al. 2013 Phase II 1st line concurrent ipilimumab + carboplatin + paclitaxel 43 33% 3.9 9.1
phased ipilimumab + carboplatin + paclitaxel 42 57% 5.2 12.5
carboplatin + paclitaxel 45 49% 5.2 10.5
Antonia et al. 2015 (CA209-032) Phase I/II 2nd line nivolumab 40 15%    
nivolumab + ipilimumab 35 25%    
NOTE: OS = overall survival; PFS = progression-free survival

Contributors: Wade T. Iams, M.D., Douglas Johnson, M.D., Christine M. Lovly, M.D., Ph.D.

Suggested Citation: Iams, W.T., D. Johnson, C. Lovly. 2015. Immunotherapy in Cancer. My Cancer Genome http://www.padiracinnovation.org/content/molecular-medicine/c2654-small-cell-lung-cancer/ (Updated September 3).

Last Updated: September 24, 2015

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