• What is STAG2?
  • STAG2 in Myelodysplastic Syndromes
  • Clinical Trials

STAG2

Stromal antigen 2 (STAG2) is a gene that codes for a subunit of the cohesin complex, which is involved in many cellular processes, such as DNA double-strand break repair and chromatid segregation during mitosis (Nasmyth and Haering 2009). Mutations in STAG2 have been observed in MDS, AML, bladder cancer, and other cancers (Losada 2014; Walter et al. 2013). Inactivation of cohesin may be a cause of aneuploidy in cancer (Gene 2014; Losada 2014).​

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Contributors: Stephen A. Strickland, M.D., MSCI, Annette S. Kim, M.D., Ph.D.

Suggested Citation: Strickland, S., A. Kim. 2015. STAG2. My Cancer Genome https://www.padiracinnovation.org/content/disease/myelodysplastic-syndromes/stag2/?tab=0 (Updated December 4).

Last Updated: December 4, 2015

STAG2 in Myelodysplastic Syndromes

STAG2 mutations occur in 2.9% of MDS (COSMIC). STAG2 mutations are most often observed in refractory cytopenia with multilineage dysplasia (RCMD) and refractory anemia with excess blasts (RAEB), two subtypes of high risk MDS (Cazzola, Della Porta, and Malcovati 2013). The role of STAG2 mutations in MDS is not yet well understood, although the cohesin complex (of which STAG2 is a subunit) is believed to be involved in myeloid leukemogenesis (Cazzola, Della Porta, and Malcovati 2013).

STAG2 mutations have been associated with less favorable clinical outcomes (Cazzola, Della Porta, and Malcovati 2013).​

Contributors: Stephen A. Strickland, M.D., MSCI, Annette S. Kim, M.D., Ph.D.

Suggested Citation: Strickland, S., A. Kim. 2014. STAG2 in Myelodysplastic Syndromes. My Cancer Genome https://www.padiracinnovation.org/content/disease/myelodysplastic-syndromes/stag2/ (Updated September 23).

Last Updated: September 23, 2014

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