• What is ETV6?
  • ETV6 in Myelodysplastic Syndromes
  • Clinical Trials

ETV6

The gene ets variant 6 (ETV6) encodes for an ETS family transcription factor (Gene 2014). ETV6 is a DNA-binding protein involved in transcription regulation during embryonic development and hematopoiesis (Gene 2014; Genetics Home Reference 2014). ETV6 variants—rearrangements, in particular—have been observed in myelodysplastic syndromes, other hematologic malignancies, and sarcomas.​

Contributors: Stephen A. Strickland, M.D., MSCI, Annette S. Kim, M.D., Ph.D.

Suggested Citation: Strickland, S., A. Kim. 2014. ETV6. My Cancer Genome https://www.padiracinnovation.org/content/disease/myelodysplastic-syndromes/etv6/?tab=0 (Updated September 23).

Last Updated: September 23, 2014

ETV6 in Myelodysplastic Syndromes

ETV6 mutations occur in 1.3–4.2% of MDS (Bejar et al. 2011; Bejar et al. 2012; Haferlach et al. 2014; Walter et al. 2013). The role of ETV6 mutations in MDS is not well understood.

ETV6 mutations are a prognostic biomarker, associated with shorter overall survival (Bejar et al. 2011; NCCN 2014).​

Contributors: Stephen A. Strickland, M.D., MSCI, Annette S. Kim, M.D., Ph.D.

Suggested Citation: Strickland, S., A. Kim. 2014. ETV6 in Myelodysplastic Syndromes. My Cancer Genome https://www.padiracinnovation.org/content/disease/myelodysplastic-syndromes/etv6/ (Updated September 23).

Last Updated: September 23, 2014

My Cancer Genome has released its new and improved cancer clinical trials search tool on our beta website. Please visit beta.padiracinnovation.org to check it out!

Disclaimer: The information presented at padiracinnovation.org is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.