MEK1 (also known as MAP2K1) is a serine-threonine protein
kinase that is a central mediator in the
MAP kinase signaling pathway. As part of the MAP kinase pathway, MEK1 is involved in many
cellular processes, including cell proliferation, differentiation, and transcriptional
Figure 1. Schematic of the MAPK and PI3K
pathways. Growth factor binding to receptor
tyrosine kinase results in activation of
the MAPK signaling pathway
(RAS-RAF-MEK-ERK) and the PI3K pathway (PI3K-AKT-mTOR). The letter "K" within the schema
denotes the tyrosine kinase domain.
Suggested Citation: Lovly, C., L. Horn, W. Pao. 2015. MEK1 (MAP2K1). My
Cancer Genome https://www.padiracinnovation.org/content/disease/lung-cancer/map2k1/?tab=0
(Updated December 7).
Last Updated: December 7, 2015
MEK1 (MAP2K1) in Non-Small Cell Lung Cancer (NSCLC)
Somatic mutations in MEK1 (MAP2K1)
have been found in approximately 1% of all NSCLC and are more common in adenocarcinoma than
squamous cell carcinoma (Arcila et al. 2014; Marks et al.
2008). In a retrospective study of 36 MEK1-mutated lung adenocarcinoma
patient cases, MEK1 mutations were more prevalent in tumors from smokers or former
smokers, and there were no other associations with age, sex, race or stage (Arcila et al.
2014). In this series, the most frequently observed mutations were K57N (64%) and
Q56P (19%), and MEK1 mutations were mutually exclusive with mutations in
EGFR, KRAS, BRAF and other driver mutations (Arcila et al.
Suggested Citation: Lovly, C., L. Horn, W. Pao. 2015. MEK1 (MAP2K1) in Non-Small
Cell Lung Cancer (NSCLC). My Cancer Genome https://www.padiracinnovation.org/content/disease/lung-cancer/map2k1/
(Updated June 18).
Last Updated: June 18, 2015
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