• What is FGFR1?
  • FGFR1 in Lung Cancer
  • Clinical Trials

FGFR1

The fibroblast growth factor receptor type 1 gene (FGFR1) encodes one member of the FGFR tyrosine kinase (TK) family, which includes four kinases: FGFR1, 2, 3, and 4 (Figure 1). FGFR TKs play crucial roles in development and have been shown in cancers to be deregulated by either amplification, point mutation, or translocation (Turner and Grose 2010). Amplification or activation of FGFR1 has been reported in many cancers including oral squamous cell carcinoma (Freier et al. 2007), breast cancer (Turner et al. 2010), esophageal squamous cell carcinoma (Ishizuka et al. 2002), ovarian cancer (Gorringe et al. 2007), bladder cancer (Simon et al. 2001), prostate cancer (Edwards et al. 2003), and lung cancer, predominantly in the squamous subtype (Dutt et al. 2011Weir et al. 2007Weiss et al. 2010).

fgfr1.png

Figure 1.
Schematic of FGFR signaling pathway. Growth factor binding to FGFR results in activation of the MAPK signaling pathway (RAS-RAF-MEK-ERK). The letter "K" within the schema denotes the tyrosine kinase domain.

Related Pathways

Contributors: Martin Sos, M.D., Roman K. Thomas, M.D.

Suggested Citation: Sos, M., R. Thomas. 2015. FGFR1. My Cancer Genome https://www.padiracinnovation.org/content/disease/lung-cancer/fgfr1/?tab=0 (Updated December 7).

Last Updated: December 7, 2015

FGFR1 in NSCLC

Amplifications of FGFR1 are predominantly found in squamous cell lung cancers from former/current smokers. The chromosomal region at 8p12 spanning the FGFR1 gene locus is amplified in up to ~20% of squamous cell lung cancer patients. Copy number changes can be detected by various techniques, including fluorescence in situ hybridization (FISH) analysis (Dutt et al. 2011Turner and Seckl 2010; Weiss et al. 2010); the exact clinically relevant cutoff levels for amplification remain to be determined. In lung cancer patients with other histologies such as adenocarcinoma, FGFR1 amplification is a rare event (less than 2%; Dutt et al. 2011Turner and Seckl 2010; Weiss et al. 2010). Preclinical data suggest that cancer cells with amplified FGFR1 can display "addiction" to FGFR signaling.

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Contributors: Martin Sos, M.D., Roman K. Thomas, M.D.

Suggested Citation: Sos, M., R. Thomas. 2015. FGFR1 in NSCLC. My Cancer Genome https://www.padiracinnovation.org/content/disease/lung-cancer/fgfr1/ (Updated June 18).

Last Updated: June 18, 2015

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