DDR2 (discoidin death receptor 2) is a
member of the DDR family of receptor
tyrosine kinases that are stimulated by
collagen rather than peptide growth
factors (Figure 1). Downstream signaling in cancer cells is poorly understood but may be via
SRC and STAT signaling pathways. Similar
to integrin receptors, DDR2 may play a
role in modulating cellular interactions with the extracellular matrix.
DDR2 mutations have been found at low
frequency in a number of cancers, including renal cell carcinoma, glioblastoma multiforme,
endometrial cancer, colorectal cancer (COSMIC).
The highest reported frequency is in squamous cell carcinoma of the lung (Hammerman
et al. 2011).
Figure 1. Schematic of DDR2 signaling pathway. Binding of collagen to DDR2 results in
activation of downstream signaling pathways.
The letter "K" within the schema denotes the tyrosine kinase
Suggested Citation: Paik, P. 2015. DDR2. My Cancer Genome https://www.padiracinnovation.org/content/disease/lung-cancer/ddr2/?tab=0
(Updated December 7).
Last Updated: December 7, 2015
DDR2 in NSCLC
DDR2 mutations have been found in
2.5–3.8% of squamous cell carcinomas of the lung and in 4% of lung tumors with
adenocarcinoma histology (COSMIC; Hammerman
et al. 2011). No hotspots have been identified, with mutations spanning both
the kinase and discoidin domains (the latter of which forms part of the extracellular region
that binds to collagen; Ichikawa et al. 2007). Neither
overexpression of DDR2 nor copy number alterations of the DDR2 locus (1q23) has
While there are limited data on the clinical characteristics of patients harboring
DDR2 mutations, no significant
association with sex, age, or smoking status has been found.
Suggested Citation: Paik, P. 2015. DDR2 in NSCLC. My Cancer Genome
(Updated June 18).
Last Updated: June 18, 2015
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