• What is CD274?
  • CD274 in Lung Cancer
  • Clinical Trials

PD-L1 (CD274)

CD274 molecule (CD274; also known as PDL1) is a gene that encodes a protein that is known as programmed cell death 1 ligand 1 (PD-L1). The protein functions in the transmission of the costimulatory signal that is needed for T-cell proliferation. Interaction with the protein inhibits T-cell activation and proliferation. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

Last Updated: January 19, 2017

PD-L1 (CD274) in Lung Cancer

As many as ~50% of lung cancers express membranous programmed cell death 1 ligand 1 (PD-L1) when less stringent cut-offs (>1%) for PD-L1 positivity are used (Huynh et al. 2016). Targeting the PD-1/PD-L1 signaling axis that leads to T cell exhaustion and subsequent immune escape by cancer cells is an emerging cancer therapeutic strategy. Antagonist antibodies to either PD-1 or PD-L1 have shown efficacy in lung cancer (see reviews in Bustamante Alvarez et al. 2015; Decatris and O’Byrne 2016; Giri et al. 2016; Leventakos and Mansfield 2016; Ohaegbulam et al. 2015; Sunshine and Taube 2015; Sznol and Chen 2013; Xia and Herbst 2016), and two antibodies to PD-1, nivolumab and pembrolizumab, have received FDA approval (Kazandjian et al. 2016; Sul et al. 2016).

Contributors: Leora Horn, M.D., M.Sc.

Suggested Citation: Horn, L. 2017. PD-L1 (CD274) in Lung Cancer. My Cancer Genome https://www.padiracinnovation.org/content/disease/lung-cancer/cd274/ (Updated January 19).

Last Updated: January 19, 2017

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