• What is AKT1?
  • AKT1 in Lung Cancer
  • Clinical Trials

AKT1

AKT1 belongs to a family of serine-threonine protein kinases which also includes AKT2 and AKT3. AKT1 plays a key role in multiple cell processes, including growth, proliferation, survival, and angiogenesis. AKT1 acts as a downstream mediator of phosphatidylinositol 3-kinase (PI3K; Figure 1).

mapk-pi3k

Figure 1.
Schematic of the MAPK and PI3K pathways. Growth factor binding to receptor tyrosine kinase results in activation of the MAPK signaling pathway (RAS-RAF-MEK-ERK) and the PI3K pathway (PI3K-AKT-mTOR). The letter "K" within the schema denotes the tyrosine kinase domain.

Related Pathways

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Contributors: Christine M. Lovly, M.D., Ph.D., Leora Horn, M.D., M.Sc., William Pao, M.D., Ph.D. (through April 2014)

Suggested Citation: Lovly, C., L. Horn, W. Pao. 2015. AKT1. My Cancer Genome https://www.padiracinnovation.org/content/disease/lung-cancer/akt1/?tab=0 (Updated December 7).

Last Updated: December 7, 2015

AKT1 in Non-Small Cell Lung Cancer (NSCLC)

Somatic mutations in AKT1 have been found in ~ 1% of all NSCLC (Bleeker et al. 2008; Do et al. 2008; Malanga et al. 2008), in both adenocarcinoma and squamous cell carcinoma histology. Preclinical data have shown that the presence of this mutation results in cellular transformation in vitro and in vivo (Carpten et al. 2007). Specific clinical characteristics of lung cancer patients harboring AKT1 mutations have yet to be described.

In the vast majority of cases, AKT1 mutations are non-overlapping with other oncogenic mutations found in NSCLC (e.g., EGFR mutations, ALK rearrangements, etc.).

Contributors: Christine M. Lovly, M.D., Ph.D., Leora Horn, M.D., M.Sc., William Pao, M.D., Ph.D. (through April 2014)

Suggested Citation: Lovly, C., L. Horn, W. Pao. 2015. AKT1 in Non-Small Cell Lung Cancer (NSCLC). My Cancer Genome https://www.padiracinnovation.org/content/disease/lung-cancer/akt1/ (Updated June 18).

Last Updated: June 18, 2015

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