Suggested Citation: Turner, N. 2015. FGFR2. My Cancer Genome https://www.padiracinnovation.org/content/disease/breast-cancer/fgfr2/?tab=0
(Updated December 7).
Last Updated: December 7, 2015
FGFR2 in Breast Cancer
The chromosomal region at 10q26 containing the FGFR2 gene
locus is amplified in about 1-2% of breast cancer patients (Jain and Turner
et al. 2001; TCGA-cBio).
Jain and Turner (2012) noted that FGFR2 amplification is uncommon in
breast cancer, but occurs a little more frequently in triple-negative breast cancer.
Fluorescence in situ hybridization (FISH) is typically used to determine whether
amplification is present. Preclinical data suggest that cancer cells with amplified FGFR2
may be sensitive to FGFR inhibitors (Bai et al. 2010; Jain and Turner
2012). Somatic FGFR2 mutations have also been observed in breast cancer (Reintjes et al.
a Data from Heiskenen et al. (2001) were
measured using microarray comparative genomic hybridization (aCGH). Data from TCGA-cBio were
measured using next-generation sequencing (NGS). Data from Turner et al. (2010) were
measured using aCGH and gene expression analysis.
Suggested Citation: Turner, N. 2013. FGFR2 in Breast Cancer. My Cancer
(Updated October 1).
Last Updated: October 1, 2013
FGFR2 Amplification in Breast Cancer
|Location of mutation
|Frequency of FGFR2 amplification in breast cancer
||1-2% (Jain and
Turner 2012; Heiskenen et al. 2001; TCGA-cBio)
|Implications for Targeted Therapeutics
|Response to FGFR inhibitors
||Unknown at this timea
|Response to anti-FGFR2 antibodies
||Unknown at this timeb
|Response to endocrine therapy
||Unknown at this time
a In preclinical studies, FGFR2-amplified cell lines are sensitive to FGFR
inhibitors (Jain and
b An FGFR2-targeting antibody
is effective in preclinical studies (Bai et al. 2010).
Suggested Citation: Turner, N. 2014. FGFR2 Amplification in Breast Cancer. My
Cancer Genome https://www.padiracinnovation.org/content/disease/breast-cancer/fgfr2/309/
(Updated October 22).
Last Updated: October 22, 2014
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