• What is AKT1?
  • AKT1 in Breast Cancer
  • Clinical Trials


AKT1 belongs to a family of serine-threonine protein kinases which also includes AKT2 and AKT3. AKT1 plays a key role in multiple cell processes, including growth, proliferation, survival, and angiogenesis. AKT1 acts as a downstream mediator of phosphatidylinositol 3-kinase (PI3K; Figure 1).


Figure 1.
Schematic of the MAPK and PI3K pathways. Growth factor binding to receptor tyrosine kinase results in activation of the MAPK signaling pathway (RAS-RAF-MEK-ERK) and the PI3K pathway (PI3K-AKT-mTOR). The letter "K" within the schema denotes the tyrosine kinase domain.

Related Pathways


Contributors: Christine M. Lovly, M.D., Ph.D., Leora Horn, M.D., M.Sc., William Pao, M.D., Ph.D. (through April 2014)

Suggested Citation: Lovly, C., L. Horn, W. Pao. 2015. AKT1. My Cancer Genome https://www.padiracinnovation.org/content/disease/breast-cancer/akt1/?tab=0 (Updated December 7).

Last Updated: December 7, 2015

AKT1 in Breast Cancer

Somatic mutations in AKT1 have been found in a fraction of breast cancers (see Table).

Gene Mutation Invasive Breast Cancer Hormone Receptor Positive (ER+ and/or PR+) Invasive Breast Cancer HER2 positive Invasive Breast Cancer Triple-negative Invasive Breast Cancer
AKT1 4% (O'Brien et al. 2010) 3.2% (Stemke-Hale et al. 2008) <1% (Stemke-Hale et al. 2008)a <1% (Stemke-Hale et al. 2008)a

a small sample size <100 patients

Contributors: Justin M. Balko, Pharm. D., Ph.D., Ingrid A. Mayer, M.D., M.S.C.I., Mia Levy, M.D., Ph.D., Carlos L. Arteaga, M.D.

Suggested Citation: Balko, J., I. Mayer, M. Levy, C. Arteaga. 2015. AKT1 in Breast Cancer. My Cancer Genome https://www.padiracinnovation.org/content/disease/breast-cancer/akt1/ (Updated June 18).

Last Updated: June 18, 2015

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