• What is NPM1?
  • NPM1 in Acute Myeloid Leukemia
  • Clinical Trials


Nucleophosmin (NPM1, also known as nuclear phosphoprotein B23, numatrin) is a gene that encodes a phosphoprotein, which is involved in the regulation of the interactions of ARF and p53. Fusions, missense mutations, nonsense mutations, frameshift insertions and deletions, and in-frame deletions and insertions are observed in cancers such as acute myeloid leukemia and skin cancer.

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Last Updated: March 30, 2018

NPM1 in Acute Myeloid Leukemia

NPM1 mutations are observed in 25–41% of patients diagnosed with AML (Chou et al. 2006; Falini et al. 2005; Papaemmanuil et al. 2016; Suzuki et al. 2005; Thiede et al. 2006). "AML with mutated NPM1" is recognized as a separate entity under the 2016 World Health Organization (WHO) classification (Arber et al. 2016) and confers a favorable prognosis in the absence of FLT3-ITD mutations. However, these patients tend to be older in age and have a worse overall survival compared to other favorable-risk AML patients (Strickland et al. 2018). NPM1 mutations fall into class II of the "two-hit" theory of leukemogenesis.​

Last Updated: March 30, 2018

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