• What is DEK-NUP214?
  • DEK-NUP214 in Acute Myeloid Leukemia
  • Clinical Trials

DEK-NUP214

DEK oncogene (DEK) is a gene that encodes a protein involved in chromatin organization, DNA damage response signaling, and DNA repair (Kavanaugh et al. 2011; UniProt 2013). In cancer, rearrangements involving DEK have been observed in AML. Its role is also being investigated in breast, head and neck, cervical, and bladder cancer, as well as in CLL.

 

Nucleoporin 214kDa (NUP214) is a gene that encodes a component of the nuclear core complex, a structure that regulates flow of material between the nucleus and cytoplasm (Gene 2013​). In cancer, rearrangements involving DEK have been observed in AML, MDS, and ALL. NUP214 is also known as CAN.

The DEK-NUP214 fusion has been primarily observed in acute myeloid leukemia.

Related Pathways

Contributors: Adam Seegmiller, M.D., Ph.D., Madan Jagasia, M.B.B.S., M.S.

Suggested Citation: Seegmiller, A., M. Jagasia. 2015. DEK-NUP214. My Cancer Genome https://www.padiracinnovation.org/content/disease/acute-myeloid-leukemia/dek-nup214/?tab=0 (Updated December 4).

Last Updated: December 4, 2015

DEK-NUP214 Fusion Gene in Acute Myeloid Leukemia

Approximately 1% of newly diagnosed AML patients have the DEK-NUP214 fusion gene (Grimwade et al. 2010; Zhang and Le Beau 2013). Also known as t(6;9)(p23;q34), DEK-NUP214 results in a protein that is capable of leukemogenesis in a small subpopulation of hematopoietic stem cells (Oancea et al. 2010). Maintenance of leukemia proceeds via separate mechanisms (Oancea et al. 2010). DEK-NUP214 fusion genes fall into class II of the “two-hit” theory of leukemogenesis (Naoe and Kiyoi 2013).

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Contributors: Adam Seegmiller, M.D., Ph.D., Madan Jagasia, M.B.B.S., M.S., Scott Wheeler, Ph.D. (through June 2014), Cindy L. Vnencak-Jones, Ph.D.

Suggested Citation: Seegmiller, A., M. Jagasia, S. Wheeler, C. Vnencak-Jones. 2014. DEK-NUP214 Fusion Gene in Acute Myeloid Leukemia. My Cancer Genome https://www.padiracinnovation.org/content/disease/acute-myeloid-leukemia/dek-nup214/ (Updated September 16).

Last Updated: September 16, 2014

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