• What is CEBPA?
  • CEBPA in Acute Myeloid Leukemia
  • Clinical Trials

CEBPA

CCAAT/enhancer binding protein, alpha (CEBPA) is a gene that encodes a protein that functions as a transcription factor that contains a leucine zipper and identifies CCAAT motifs in the promoter regions of gene targets. Missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame insertions and deletions are observed in cancers such as hematopoietic and lymphoid cancers, cervical cancer, and intestinal cancer.

Last Updated: March 30, 2018

CEBPA in Acute Myeloid Leukemia

CEBPA mutations are observed in 8–19% of patients diagnosed with AML (Benthaus et al. 2008; Bienz et al. 2005; Forhling et al. 2004; Pabst et al. 2001; Schlenk et al. 2008). "AML with CEBPA biallelic mutation" is recognized as a separate entity under the 2016 World Health Organization (WHO) classification (Arber et al. 2016) and confers a favorable prognosis in absence of concurrent FLT3-ITD mutations. CEBPA mutations fall into class II of the “two-hit” theory of leukemogenesis.​

Last Updated: March 30, 2018

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