• What is CBFB-MYH11?
  • CBFB-MYH11 in Acute Myeloid Leukemia
  • Clinical Trials

CBFB-MYH11

Core-binding factor, beta subunit (CBFB) is a gene that codes for the beta subunit of the core binding factor protein. This protein is thought to take part in normal hematopoiesis (Gene 2013a). CBFB is involved in rearrangements observed in AML. Its role in cancer is also being investigated in breast cancer.

Myosin, heavy chain 11, smooth muscle (MYH11), is a gene that encodes for a contractile protein in muscles (Gene 2013b​). MYH11 is involved in rearrangements observed in AML.

The CBFB-MYH11 fusion has been primarily observed in acute myeloid leukemia.

Contributors: Adam Seegmiller, M.D., Ph.D., Madan Jagasia, M.B.B.S., M.S.

Suggested Citation: Seegmiller, A., M. Jagasia. 2013. CBFB-MYH11. My Cancer Genome https://www.padiracinnovation.org/content/disease/acute-myeloid-leukemia/cbfb-myh11/?tab=0 (Updated June 4).

Last Updated: June 4, 2013

CBFB-MYH11 Fusion Gene in Acute Myeloid Leukemia

The CBFB-MYH11 fusion gene, inv(16)(p13.1;q22) or t(16;16)(p13.1;q22), is observed in about 5% of newly diagnosed AML patients (Grimwade et al. 2010; Zhang and Le Beau 2013). Research suggests that this fusion gene, in combination with other mutations, can result in leukemogenesis (Kundu and Liu 2001). CBFB-MYH11 fusion genes fall into class II of the “two-hit” theory of leukemogenesis (Naoe and Kiyoi 2013).​

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Contributors: Adam Seegmiller, M.D., Ph.D., Madan Jagasia, M.B.B.S., M.S., Scott Wheeler, Ph.D. (through June 2014), Cindy L. Vnencak-Jones, Ph.D.

Suggested Citation: Seegmiller, A., M. Jagasia, S. Wheeler, C. Vnencak-Jones. 2013. CBFB-MYH11 Fusion Gene in Acute Myeloid Leukemia. My Cancer Genome https://www.padiracinnovation.org/content/disease/acute-myeloid-leukemia/cbfb-myh11/ (Updated September 9).

Last Updated: September 9, 2013

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