Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson's disease.

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The scientists here recently demonstrated that human induced pluripotent stem cells derived mDA progenitors grafted into the substantia nigra pars compacta in a mouse model of Parkinson disease, differentiated into mature mDA neurons, restored the degenerated nigrostriatal pathway, and induced motor recovery. The objective of the present study was to evaluate the long-term functionality of these intranigral-grafted mDA neurons by assessing their electrophysiological properties.

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